Case I.—The Nervous, Neuralgic, or Rheumatoid Type.—One of the earliest cases which I saw was that of a lady, who was seized on the evening of Friday, December 20, 1889, and who was seen next morning by my friend, Dr. James Craig, one of the Assistant Physicians to the Meath Hospital. The following is the lady’s own account of her attack:—“Friday, Dec. 20th, 1889, I went to the oratorio at St. Patrick’s Cathedral apparently in my usual health. Shortly after entering the Cathedral I felt Chilled, as if cold water was being poured down by back and legs. When I returned home I warmed myself at a good fire, was given some hot wine and water, and went to bed; then my face and head got very hot and uncomfortable, and pains began in my arms, shoulders, and legs. All night the pains were very bad, sometimes so sharp across the back of my chest that I could have cried out; and, although I felt burning to the touch, the cold-water sensation continued. I got no sleep that night. Next day, about twelve o’clock (mid-day), I was given a powder (Salicylate of sodium) and in two hours afterwards another, which put me into a perspiration. The pains in my limbs got better but my head began to ache badly and all day I felt very ill. I suffered from